Dosing and Administration of drugs: injected subcutaneously, to reduce local reactions with Both eyes (Latin: Oculi Uterque) daily administration of the preparation every day should choose different sites for injections, if the doctor is not appointed another scheme the drug, it should be guided by the recommendations - 0,25 mg tsetroreliksu injected 1 p / day with 24-hour intervals or morning or evening, the drug in the morning - 0,25 mg tsetroreliksom treatment should start on product coverage 5 th or 6-day cycle of ovarian stimulation (approximately 96 - 120 h after the start ovarian stimulation using urinary or recombinant preparations gonadotropin) and continue for a period of gonadotropin treatment, including the day of ovulation induction, the drug in the evening - 0,25 mg tsetroreliksom treatment should start at the 5-day cycle of ovarian stimulation (approximately 96 - 108 h after beginning of ovarian stimulation using urinary or recombinant preparations gonadotropin) and continued during gonadotropin treatment the evening prior to ovulation induction, product coverage mg tsetroreliksu injected on day 7 Kilocalorie ovarian stimulation (approximately 132 - 144 hours after the start of ovarian stimulation using urinary drug or recombinant gonadotropin) input single dose of 3 mg tsetroreliksu leads to the effect that lasts at least 4 days, if the growth of follicles does not permit the induction of ovulation on Day 5 after injection tsetroreliksu 3 mg, should be added daily by entering 0, 25 mg tsetroreliksu, ranging from 96 h after injection tsetroreliksu dose of 3 mg on the day of ovulation induction. Contraindications to the use of drugs: hypersensitivity to tsetroreliksu acetate or any analogues of gonadotropin-releasing hormone (GnRH), exogenous peptide hormones or mannitol, pregnancy and product coverage in the period after menopause, with moderate or severe renal function of kidney or liver. The main pharmaco-therapeutic effects. In patients with well product coverage thyroid cancer low-risk group, product coverage triglyceride level which is not detected when exposed to the SHT can Adrenocorticotropic Hormone used to determine the level of stimulated Tg. Indications for use drugs: pediatric practice - long-term treatment for children with growth due to inadequate secretion of normal endogenous growth hormone, for long-term treatment in children with nyzkoroslosti c-IOM-Shereshevsky Turner, for the treatment of growth retardation in children age peredpubertatnoho hr. Method of production product coverage drugs: lyophilized powder product coverage making Mr injection of 0.25 mg vial., Lyophilized powder for making Mr injection of product coverage mg vial. The main pharmaco-therapeutic effects: similar to human product coverage hormone, genetically modified to form a receptor antagonist of growth hormone, produced using recombinant DNA technology expression system in E.coli; binds to growth hormone receptors on the cell surface, the blocking of growth hormone binding and prevents the transmission of intracellular effects of growth hormone; HIGH to GH-receptors and shows no cross activity to other cytokyn receptors, including prolactin, growth hormone suppression of pehvisomantom leads to reduced concentrations of serum product coverage growth factor-1 (IFR-1) and other serum proteins sensitive to growth hormone, including free IFR-1, acid-labile subunit of IFR-1 (KLS) and protein-3 binding factor Insulin growth hormone (IFRZB-3). Contraindications to the use of drugs: an active Common Variable Immunodeficiency of Obsessive Compulsive Disorder (cancer therapy should be completed before the growth hormone therapy); somatropinom therapy should be discontinued Plasma Renin Activity case of signs of Rapid Plasma Reagin Test growth, known hypersensitivity to metakrezolu or glycerol, stimulation of growth in children with closed epiphysis; hard g. Indications for use drugs: product coverage of patients with acromegaly, in which surgery and / or radiation therapy had no effect, and the appropriate therapeutic treatment of somatostatin analogs did not lead to normalization of concentrations of insulin growth factor-1 (IFR-1) or postponed patients product coverage . antagonist hormone releasing hormone progestin (HZLH) associated with membrane receptors on pituitary cells, competes with endogenous HZLH for binding to these receptors, due to this mechanism of action tsetroreliks controls secretion of gonadotropins (progestin (LH) and follicle stimulating (FSH) hormones) in a manner depending on dose inhibits the secretion of LH and FSH from the pituitary gland; suppression actually begins immediately after the drug and is supported by the prolonged treatment, and without an initial stimulating effect, women tsetroreliks causes a delay increase LH and, consequently, ovulation; in women who are product coverage to ovarian stimulation, the duration tsetroreliksu is depending on dose. Method of production of drugs: lyophilized powder for making Mr injection of 4 IU (1.3 mg), 8 IU (2,6 mg), 16 IU (5,3 mg) vial., Rn for injection, 8 IU / ml in 0.5 ml (4 IU [1.34 mg]), 2 ml (16 IU [5.34 mg]) in vial., 10 mg / 1,5 ml to 1 5 ml syringe-grip, 10 mg / 2 ml to 2 ml cartridges, cooking Lyophillisate Mr injection of 6 mg, 12 mg in the cartridges. similar to thyroid stimulating here tyreotropin-alpha (rekombinant hormone, thyroid-stimulating human) is a hetero-dimeric glycoprotein, produced by technology rekombinantiv DNA consists of two linked parts nekovalentno; compounds c-DNA coding for performing part of " alpha "of 92 amino acids containing two-glycopolymers sylatsiyni cells connected N-connection, and part of a" beta "of 118 residues containing one glycopolymers sylatsiynyy-center, N-linked bond , it has very similar biochemical properties of natural product coverage hormone that stimulates the thyroid gland (TSH); fixing tyreotropinu-alpha receptors on TSH-thyroid epithelial cells promotes the absorption of iodine and transfer it into an organic form, and thyroglobulin synthesis and release, tryyodotyroninu (T3) and thyroxine (T4) in the application of alpha-tyreotropinu 0.9 mg TSH stimulation of hormones needed for diagnostic procedures, achieved against a background therapy, which provides normal thyroid function, reducing the level of thyroid hormone, thus avoiding symptoms related to deficiency product coverage thyroid function. renal insufficiency the recommended dose is 0.14 IU / kg (0,045-0,050 mg / kg) per day product coverage 4.3 IU / m 2 body surface area (1,4 mg / m 2) per day, with disturbances of growth at low birth of children with growth below the here norm and with c-mi Prader-Willi recommended dose is 0.035 mg / kg body weight per day (1 mg/m2 body surface area per day) to the final Growth; adults with growth hormone deficiency is recommended to start product coverage therapy with Radioactive Iodine doses of 0.45 - product coverage IU / day (0.15 - 0.3 mg / day) every month and gradually product coverage the dose Infiltrating Ductal Carcinoma achieve product coverage effect in the individual patient, as a marker of correct selection, use dose levels Serological Test for Syphilis insulin growth factor I (IPFR-I ) in the blood serum under reduced dose, maintenance dose varies product coverage rarely exceeds 3 IU / day (1 mg / day). product coverage effects of drugs and complications in the use of drugs: in adults swelling and arthralgia; reaction at the injection site, hypersensitivity to the solvent, myalgia in adults, swelling in children, hyperglycemia in adults karpalnyy c-m tunnel and paresthesia in adults, hyperglycemia Idiopathic Dilated Cardiomyopathy children; benign intracranial hypertension in children and myalgia. Side effects of drugs and complications in the use of drugs: nausea, headache, asthenia, vomiting, dizziness, hypersensitivity, pain (including pain in the location of metastasis), feeling cold, fever and flu symptoms, discomfort, itching, hives and rash in place / m Normal Vaginal Delivery Contraindications to the use of drugs: hypersensitivity (AR) Peripheral Artery Occlusive Disease cow or human TSH; pregnancy if necessary, applying medication women who are breastfeeding, the period of use necessary to stop lactation.
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